What is Retatrutide?
Retatrutide is a medication developed to treat obesity. It is a weekly injectable medication in a group of drugs called GLP-1 receptor agonists (or GLP-1 mimickers). It is unique in the fact that it works on 3 incretin hormones (GLP-1, GIP, and Glycogen) as opposed to other GLP-1 and GIP medications that only attach to one or two hormones. Therefore, due to Retatrutide’s triple activity, it has shown about 24.2% weight loss compared to 15-20% of weight loss shown by Semaglutide (Wegovy) or Tirzepatide (ZepBound).
What are the benefits of Retatrutide?
Unique Triple-Action Mechanism: The “Triple G” nickname comes from its ability to target three different hormone receptors.
- GLP-1: Helps regulate insulin, slows gastric emptying, and promotes satiety, leading to reduced appetite.
- GIP: Also helps regulate blood sugar and promotes fat metabolism.
- Glucagon: Increases energy expenditure and may contribute to enhanced fat loss.
- Promotes lipolysis (which is the breakdown of fats)
- Improves blood sugar levels in adults with Type 2 diabetes
- Slows down gut digestion, therefore, you stay fuller longer
- Lowers BMI by helping with weight loss
- Helps pancreatic insulin release to lower glucose levels in the bloodstream
- Helps reduce appetite and helps to control food cravings
How Does Retatrutide Work?
Retatrutide attaches to three receptors (GLP1, GIP, and Glucagon), unlike previous GLP-1 analogs which only attach to one or two, resulting in increased overall weight loss (around 24.2%). GLP-1 medications mimic a hormone called GLP-1 that the body releases after a meal, signaling fullness and lowering appetite.
It also slows gastric emptying, so food moves slower through the stomach. The price of the shot per week is dependent on the dose. You will start on the lowest dose and gradually work your way up.
Are There Side Effects?
Some studies show negative side effects which may include nausea, constipation, reflux, diarrhea, abdominal pain, and even vomiting with GLP-1 agonist medications. However, this is not for every individual that uses GLP-1 medications.
What is the dosing/Pricing?
Pricing does vary depending on the dose.
- 2.5mg-$85/wk
- 5mg-$105/wk
- 7.5mg-$135/wk
- 10mg-$155/wk
- 12.5mg-$205/wk
- 15mg-$255/wk
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